P823

         Arch Int Pharmacodyn Ther 1984 Jan;267(1):123-30

        Functional residual lung capacity in rats affected by a carotid body

        stimulant.

        Paleček F, Chválová M.

        The respiratory response and changes of functional residual lung

        capacity were measured in the rat after intravenous administration of

        the drug S 2620 in a dose of 0.4 mg/kg. This substance induced a

        significant decrease of arterial PCO2 and an increase of minute

        ventilation. The stimulating effect of S 2620 was maximal in the 10th

        min; after 60 min, ventilation and PCO2 approached control levels. The

        CO2 ventilatory response was determined 10 min after the administration

        of S 2620. The slope of the control and S 2620 stimulated curves was

        similar with a shift towards higher ventilation and lower PCO2 after S

        2620 administration. Functional capacity rose with increasing minute

        ventilation. The increase of functional residual capacity disappeared

        after bilateral cervical vagotomy.